Educational Module - Neuroendocrine Disorders Post Acquired Brain Injury

Neuroendocrine Disorders Post Acquired Brain Injury

History and Epidemiology

Neuroendocrine disorders, primarily hypopituitarism, was first diagnosed by the Germanresearcher Cyran in 1918 1-3. Until recently damage to the hypothalamus and pituitary gland following trauma was often not diagnosed until the post mortem examination 17. Recent research indicates neuroendocrine disorders vary post traumatic brain injury (TBI) 18and what was once thought to be a rare occurrence is now increasingly diagnosed 1;19;20.  In the early 1950’s, the incidence of hypopituitarism post injury was thought to be 1%; however, the rate has recently been quoted between 20 and 70% 3;14.

What does the research tell us about the pooled prevalence of hypopituitarism post stroke and ABI?

1.    The pooled prevalence of hypopituitarism post TBI was 27% and post stroke it was 47%.

2.    Neuroendocrine abnormalities, hypopituitarism and growth hormone deficiencies are common amongst those who sustain a TBI, especially those who stustain a moderate to severe TBI.