11. Heterotopic Ossification & Venous Thromboembolism

Robert Teasell MD FRCPC, Shannon Janzen MSc, Rachel Anderson BSc, Caitlin Cassidy MD,  Shawn Marshall MD FRCPC, Nora Cullen MD FRCPC

 

Chapter 11 Abbreviations 

Heterotopic ossification (HO) is the formation of pathologic bone within soft tissues, often muscle tissues, where bone formation does not usually occur (Watanabe & Sant 2001). The incidence of HO in patients with traumatic brain injury (TBI) has been reported to range from 11% to 77% but is clinically relevant in 10-20% (Dizdar et al. 2013; Garland et al. 1980; Rogers 1988; Sarafis et al. 1999; Sazbon et al. 1981; Zychowicz 2013). Risk factors include skeletal trauma, spasticity, diffuse axonal injury, mechanical ventilation, prolonged immobilization, and injury severity (Moreta & De los Mozos 2014). HO is often quite painful and limits joint mobility; the restricted joint range of motion may exacerbate disability and impede progress towards desired rehabilitation goals.