What is the evidence for the use of trazadone in the management of agitation and aggressive behavior?

  1. There is evidence that early treatment with Trazadone is a safe and effective treatment for controlling agitation post TBI.
  • Trazodone is antidepressant with a sedation effect and may useful for the treating of insomnia after TBI 26.
  • It has been found to be effective when administered for the early treatment of post-traumatic brain injury agitation 21.
  • There is Level 4 evidence that early multiple neuropharmacological treatment that including trazodone may be effective for agitation after TBI 43.